It is possible to connect up to 8 multiplexers to the same I2C bus, this is accomplished using the Address jumpers on the multiplexer board.
Connect the FT230XC USB to I2C adapter to the computer via I2C. Connect it’s I2C port to the I2C in on the first multiplexer, then connect the I2C Out of that multiplexer to the I2C in of the second multiplexer(make sure jumper is install on the Address 0 pins for the second multiplexer).